Cells need to communicate with each other to exchange information and fulfil their physiological role. In addition to direct cell-to-cell contact and the exchange of certain soluble factors, there is a third route of information transfer, which has recently received significant attention - extracellular vesicles. These small, nanometer-sized particles are responsible for the exchange of small and large molecules between cells and tissues, and thus affect our body in many ways. In the past years, researchers have asked many fundamental and applied questions to better understand this process. And because many of these questions in this exciting field of research are still open, we decided to publish a new journal - Trillium Extracellular Vesicles.