Company nameHamamatsu PhotonicsRoche Diagnostics Deutschland GmbHSysmex Deutschland GmbH 
3DHISTECH LTD
 
Model nameNanoZoomer S540MD NanoZoomer S20MDVentana DP600Ventana DP200Pannoramic 480 2nd Gen. 
System dataType of constructionBenchtop or placed on cartBenchtop Integrated, compact benchtop deviceIntegrated, compact benchtop device Integrated, benchtop
Width x height x depth (cm)75 x 64 x 6948 x 45 x 6174 x 74 x 6750 x 68 x 46119 x 100 x 90
Weight (kg)123.6 (188.6 with cart)5275 + 11 (Touchscreen Monitor + PC)46,5 + 11 (Touchscreen Monitor + PC)240
Supported slide dimensions
(width x length x thickness in mm)
25–26 x 75–76 x 0.9–1.225–26 x 75–76 x 0.9–1.225–26 x 75–76.5 x 0.9–1.4Single: 25–26 x 75–76.5 x 0.9–1.4
Double: 51–52 x 75–76.5 x 0.9–1.4
Single: 25–26 x 75–76 x 0.9–1.2
Double: 50–51 x 75–76 x 0.9–1.2
Slide handlingAutomated, horizontalAutomated, horizontalHorizontal, slide remains in the tray (exclusion of glass breakage)Automated, horizontal
Lenses (magnification | numerical aperture)20x | 0.7520x | 0.7520x | 0.75 (Nikon ApoChromat, WD = 1.0 mm, additional LS for 40x)20x | 0.8; 40x | 0.95; 40x | 1.2
(water immersion)
Resulting magnification per lens (x-fold)20x; 40x20x; 40x20x; 40x20x; 40xUp to 57x; 113 x; 113x (depending on camera type)
Pixel resolution (µm/pixel) per lens20x: 0.46; 40x: 0.2320x: 0.46; 40x: 0.2320x: 0.46; 40x: 0.2520x: 0.46; 40x: 0.250.18; 0.09 (depending on camera type)
Digital image sensor (type | pixel MP)CMOS | –CMOS | –CMOS Tri-Linear | 24CMOS Tri-Linear | 24CMOS | 12; 21; 25 (depending on configuration)
Image processingAutomatic white balance, auto focusAutomatic white balance, auto focusAutomatic white balance, ICC color profiles, dynamic autofocus, AI-supported tissue recognitionAutomatic white balance, auto focus,
color calibrated
Supported microscopy methodsBrightfield microscopyBrightfield microscopyBrightfield microscopyBrightfield microscopyBrightfield microscopy, polarization (optional)
Light source typesLEDLEDLEDLEDPulsed xenon lightsource 
Performance dataSlide loader (type | loading capacity)

540 slides | 30 slide cassettes;

360 slides | 20 slide cassettes

20 slides | 1 cassetteSlide tray | 40 trays with 6 slides each 
(240 in total)
Slide tray | 1 tray with 6 slidesRacks | up to 480 slides
Supported stainer racks (type)

Sakura 4768 20-slide cassette;

Leica Universal 30-slide cassette

Sakura 4768 20-slide cassette;

Hamamatsu Slide cassette

Sakura, Leica
Image formats (incl. conversion)NanoZoomer Digital Pathology Image (NDPI), DICOMNanoZoomer Digital Pathology Image (NDPI), DICOMBIF, TIF, DICOMBIF, TIF, DICOMNative: MRXS, DICOM, export to svs or tiff
Z-stacks (number | distance)1–99 layers | up to 100 μm1–99 layers | up to 100 μm15 | 0.5–1.5 μm30 | 0.2–10 µm
Scanning speed for an area of 15 x 15 mm (enlargement I sec.)20x; 40x | approx. 30 sec (area of 15 mm × 15 mm square with 5 focus points)20x | 36 sec;
40x | 73 sec
40x | approx. 30 sec
Throughput: slides/h≥ 828020x: approx. 70 (time to view);
40x: approx. 40 (time to view)
80
Integrated QC and IndicationYes, manual QC or integrated focus score, with possibility of automatic rescan at specified score levelsYes, manual or automatic advanced image quality checkYes, manual image quality checkInternal QC for focus quality
Integration and NetworkingViewer

Stand-alone, included with NZAcquireMD software, or optional web-based server managed 

software for scanning and viewing

Slide Viewer (stand-alone), navify Digital Pathology IMS (web-based)Stand-alone and web-based
AI-SupportYes, intelligence mode tissue detection to detect areas of tissue on the slide macro imageYes, with navify Digital Pathology IMSYes, AI supported tissue detection
Works with Cloud and/or onPremCloud and on-prem storageCloud and on-prem storage Slide Viewer (on-prem), navify Digital Pathology IMS (cloud)On premise
Self-calibrationAutomatic self-correctionYesYesYesYes
STAT mode, prioritised slidesYes, prioritise and organise the scanning order of racks or slides. Yes, although it is not required with a low capacity scanner you can define the order of scanning. Yes, trays can be prioritizedYes 
Barcode scanner (1D, 2D)Barcode driven workflow with 1D and 2D barcode support1D, 2D: DATAMATRIX, PDF417, QR code1D, 2D: DATAMATRIX, PDF417, QR code1D, 2D
Image data managementHamamatsu image formats are compatible with all major providers of image management software. We can also provide our NZConnect software for management of images. IVD-compliant IMS for diagnostics (also across locations): navify Digital PathologyRX: SlideCenter; DX: CaseManager
Interface protocols

Supports HL7 interfacing and automated DICOM image distribution to IMS, PACS, and VNA for 

efficient data exchange

HL7, DICOMHL7, DICOMHL7
Connection to LIS/PIS HL7 interfacing for LIS and PIS integration, automated LIMS data association via barcode recogni-tion, bidirectional communication with LIS/PIS, NZConnect API for custom LIS/PIS integration.YesYesYes
CertificationsCompliant with IVDR, IvDO and UK MDR2002CE-IVD, FDACE-IVD, FDADX: IVDR
DICOM supportedYesYesYesYesYes
Embeds color profileEmbedded CCMEmbedded CCMICC color profilesICC color profilesYes
Software development kit (SDK) availableYesYesOn requestOn requestYes, 3DHistech SimpleSlideInterface
Unique selling points, special features

The NanoZoomer S540MD is a large capacity, high-throughput, automated scanner that 

seamlessly integrates to lab environments. With Sakura cassettes support, touchscreen interface it is intuitive requiring minimal user input. 

The NanoZoomer S20MD is a high-speed, compact, and adaptable scanner that adds flexibility and scalability to your digital pathology workflow.

It supports Sakura cassettes and automatic

scanning for minimal user input. 

Medium to high throughput in histopathological routine diagnostics, CE-IVD system, can be
combined with the IMS navify Digital Pathology and thus access to a variety of algorithms is possible
Scanning of double-width slides is possible,
ideal for frozen section application, CE-IVD system, suitable for cytology and histopathology, combinable with the IMS navify Digital Pathology and thus access to a variety of algorithms is possible
With all-in-one Server PC with up to 40 GB
storage, only high-troughput scanner with 40x objective, water immersion or polarization mode, RX package includes IMS (SlideCenter) and quantification software, DX package in-cludes IMS (case manager), viewer and diagno-stic applications AI and monitoring software
ContactHamamatsu Photonics 
Deutschland GmbH
Erk Klopp
+49 8152 375 212

www.hamamatsu.de
Roche Diagnostics 
Deutschland GmbH
Julia Schiffer 
+49 173 586 1010

www.roche.de
Sysmex Deutschland GmbH
Olaf Scheel
+49 174 378 7092

www.sysmex.de

Download Overview of scanner for Digital Pathology