Crossroads of the endosomal machinery:

Multivesicular bodies, small extracellular vesicles and autophagy

The primary role of endosomal system is endocytic trafficking – to sort out internalized macromolecules and proteins to their destined cellular localizations. Incorporation of sorted cargos into multivesicular bodies (MVBs) confers specificities and determines their fates. This central point of the endosomal trafficking separates MVBs in two directions. The MVB populations fuse either with lysosomes to initiate autophagy or with plasma membrane to release small extracellular vesicles...

Keywords: Exosomes; degradative MVB; secretory MVB; physiological stress; endocytic machinery; lysosome