“Brainstorming”:

Extracellular Vesicles in Physical Activity and Neuronal Health

Physical and mental activity are known to contribute to brain health and overall longevity. Extracellular vesicles (EVs) have attracted attention for their ability to transport bioactive cargo through various body-fluids and their role in tissue crosstalk and regeneration. Targeted intercellular communication processes, including those facilitated by EVs, are of vital importance for the complex architecture and function of the brain. Activated neurons trigger the transfer of EVs from myelinating oligodendrocytes to neurons, promoting neuronal long-term maintenance and survival...

Keywords: oligodendrocytes, neuron-glia interaction, extracellular vesicles, physical exercise, neuronal maintenance, neuroprotection